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Article Ru | MEDLINE | ID: mdl-23739436

Authors have studied the efficacy of adaptol and neyromidin in the combined treatment of patients with chronic cerebral circulation insufficiency and consequences of closed head injury using neurophysiological monitoring which included dynamic evaluation of central conductivity, neuropsychological tests and analysis of blood BDNF levels. Severe autonomic disorders, anxiety and low level of learning observed in all patients are correlated with neurophysiological (increased central conductivity time) and neurotrophic (decreased blood BDNF levels) profiles. These indicators may change throughout the treatment. The combination of adaptol and neyromidin enhanced greatly the efficacy of combined treatment. The received data allow recommending neurophysiological monitoring for treatment optimization of numerous neurological diseases that demand neuroplasticity stimulation.


Brain Injuries/drug therapy , Brain Ischemia/drug therapy , Adolescent , Adult , Aged , Aminoquinolines/adverse effects , Aminoquinolines/therapeutic use , Anxiety/drug therapy , Biureas/adverse effects , Biureas/therapeutic use , Brain Injuries/diagnosis , Brain Injuries/physiopathology , Brain Ischemia/diagnosis , Brain Ischemia/physiopathology , Brain Waves/drug effects , Brain-Derived Neurotrophic Factor/blood , Drug Therapy, Combination , Female , Humans , Learning/drug effects , Male , Middle Aged , Neuronal Plasticity/drug effects , Neuropsychological Tests , Treatment Outcome
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